Pleshette had a long career in film, television and stage, including schoolteacher Annie Hayworth in the Alfred Hitchcock film The Birds (1963). After a string of TV shows including Dr Kildare, Gunsmoke, Bonanza, Marcus Welby MD, she is well-remembered as the wife of the neurotic Newhart.
She later guest-starred as Katey Sagal’s mother, Laura Egan, on 8 Simple Rules. Her last role was in Will and Grace as the estranged mother of Karen Walker.
Pleshette, who underwent chemotherapy for lung cancer in 2006, died of respiratory failure Saturday evening at her Los Angeles home, said attorney and family friend Robert Finkelstein.