Stoner, who was one of TV’s most glamorous stars, is best known for Cop Shop, The Paul Hogan Show, The Young Doctors and Prisoner. She is a long-standing advocate for animal rights.
She will stand for the Senate in New South Wales and has previously stood unsuccessfully for a seat in the NSW Parliament.
“On shows like Cop Shop, we were a tight-knit group and there was lots of laughter and camaraderie. I am also grateful for the public profile it gave me so that I could speak up for animals,” she told News Corp.
“I am also excited by the fact that more and more Australians recognise that animals need a voice.”
Stoner’s former fiancé Derryn Hinch is also standing for the Senate, for the Justice Party.