Warner Bros. cuts ties with producer, director Brett Ratner.

Major studio will not renew production deal after allegations levelled at blockbuster producer / director.

Warner Bros. is severing ties with producer, director Brett Ratner after six women publicly accused him of a range of sexual harassment and misconduct.

Ratner, who formed RatPac Entertainment with James Packer, is behind such titles as Prison Break, Rush Hour, The Revenant, X-Men: The Last Stand. Packer sold his share to Access Entertainment earlier this year.

The LA Times reports  the fate of a $450-million co-financing agreement with RatPac and Dune Entertainment beyond 2018 is now unclear. Earlier it issued a statement, “We are aware of the allegations in the LA Times and are reviewing the situation.”

Earlier it detailed allegations by actresses including Olivia Munn, Natasha Henstridge and Jaime Ray Newman, including masturbating in front of women to forcing them into oral sex.

Ratner “categorically” disputed the women’s accounts.

“In light of the allegations being made, I am choosing to personally step away from all Warner Bros.-related activities,” Ratner, 48, said in a statement. “I don’t want to have any possible negative impact to the studio until these personal issues are resolved.”

RatPac-Dune Entertainment is financing several films that remain on the studio’s upcoming slate: the upcoming Justice League movie (due out Nov. 17), Father Figures, Clint Eastwood’s 15:17 to ParisGame Night, the Tomb Raider reboot and Steven Spielberg’s Ready Player One. A project with Jared Leto to play Playboy mogul Hugh Hefner is now on hold.